Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, we assessed whether the functional single nucleotide polymorphism (SNP) on the BDNF gene, Val66Met, moderated the relationship between depressive symptoms and perceived social support and unsupportive relationships, and whether these associations differed by gender.
|
31364951 |
2020 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF (rs6265) and CRY1 (rs2287161) variants have been associated with more depressive symptoms in people with PD.
|
31292011 |
2020 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson's disease (PD) and whether exercise responses were influenced by brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.
|
31197095 |
2019 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest a close relationship between job-related stress and depression, and the interaction of the BDNF Val66Met polymorphism and chronic stress in adulthood may impact the depressive symptoms.
|
29734099 |
2018 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
A BDNF Val66Met × Harsh Parenting interaction predicted the rise in depressive symptoms across a 3-year period, whereas a 5-HTTLPR × Harsh Parenting interaction predicted greater frequency in elevated depressive symptoms.
|
27736236 |
2018 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our investigation assessed whether indices of white matter integrity, serotonin transporter-linked polymorphism (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) val66met polymorphism predicted magnitude of depression symptom change following antidepressant treatment.
|
27277475 |
2017 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
i) GG homozygotes (rs1475157-NRN1) showed higher scores on BSI depressive dimension and on total scores compared to A carriers (corrected p-values: 0.0004 and 0.0003, respectively). ii) a linear trend was detected between GG genotype of rs1475157 and a worse cognitive performance in WCST total correct responses (uncorrected p-value: 0.029). iii) Interaction between rs1475157-NRN1 and Val66Met-BDNF was found to modulate depressive symptoms (p=0.001, significant after correction).
|
28107668 |
2017 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a significant interaction between C-reactive protein (CRP) and the BDNF Val66met polymorphism in predicting cognitive depressive symptoms (p=.004), such that higher CRP was related to more cognitive depressive symptoms among Met allele carriers, but not among Val/Val homozygotes.
|
26967918 |
2016 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29).
|
27742526 |
2016 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results indicated the BDNF Val66Met polymorphism significantly moderated the influence of maternal warmth-reasoning, but not harshness-hostility, on youth depressive symptoms.
|
26510938 |
2016 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study has provided the first examination of whether working memory capacity, the BDNF Val66Met polymorphism, and their interaction predict changes in symptoms of depression during the transition to university.
|
24920443 |
2015 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We modeled the interactive effects of peer victimization with three genetic polymorphisms (on 5-HTTLPR, DRD2 TaqIA, and BDNF Val66Met) on depressive symptoms.
|
24819687 |
2015 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study represents the first replication of the BDNF Val66Met ⁎ 5-HTTLPR ⁎ childhood maltreatment effect on self-reported depression symptoms using a rigorous maltreatment interview.
|
26070769 |
2015 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study examined the effects of val66met, 5-HTTLPR, and family environment quality on youth depressive symptoms in adolescence and young adulthood in a longitudinal sample oversampled for maternal depression history.
|
25347540 |
2014 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the BDNF Val66Met polymorphism influenced responses to add-on memantine by decreasing depressive symptoms in patients with BP-II.
|
24103632 |
2014 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In midlife, the BDNF Val66Met polymorphism neither attenuates nor magnifies the effect of physical activity on depressive symptoms.
|
24745471 |
2014 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, the BDNF Val66Met polymorphism is a significant factor influencing the severity of anxiety/depression symptoms in schizophrenic patients.
|
23532065 |
2013 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism was independently associated with prevalent PSD, but not with persistent and incident PSD nor with depressive symptoms severity.
|
23399480 |
2013 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Role of the Val66Met Polymorphism of the Brain Derived Neurotrophic Factor Gene in Coping Strategies Relevant to Depressive Symptoms.
|
23824678 |
2013 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms: a prospective study.
|
23058261 |
2013 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both 5-HTTLPR and BDNF Val66Met interacted with unfavourable environment in relation to depressive symptoms (Adj R²=0.19).
|
23481907 |
2013 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms.
|
23140671 |
2013 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that the BDNF rs6265 polymorphism was related to the severity of depressive symptoms, and that this association was independent of neurotransmitter levels.
|
21898033 |
2012 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequency of stressful life events was significantly correlated with depressive symptoms (twin1: β = 0.21, P = 0.01; twin2: β = 0.27, P < 0.01), but there was no significant main effect of the BDNF Val66Met genotype on depressive symptoms.
|
22931410 |
2012 |
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects.
|
21420735 |
2011 |